Coffee Break is a resource at NCBI that combines reports on recent biomedical discoveries with use of NCBI tools. The result is an interactive tutorial that tells a biological story. Each report is based on a discovery reported in one or more articles from the recently published peer-reviewed literature. After a brief introduction that sets the work described into a broader context, the report focuses on how a molecular understanding can provide explanations of observed biology and lead to therapies for diseases.
***The Computational Photography Project for Pill Identification (C3PI) was discontinued in 2018. No new images will be added to the collection. Identifiers for pills will not be updated.***
The Computational Photography Project for Pill Identification (C3PI) created the RxIMAGE database of freely available high-quality digital images of prescription pills and associated data for use in conducting computer vision research in text- and image-based search and retrieval. Photographs of pills for the RxIMAGE database were taken under laboratory lighting conditions, from a camera directly above the front and the back faces of the pill, at high resolution, and using specialized digital macro-photography techniques. Image segmentation algorithms were then applied to create the JPEG images in the database.
The Consensus CDS (CCDS) project is a collaborative effort to identify a core set of human and mouse protein coding regions that are consistently annotated and of high quality. The long term goal is to support convergence towards a standard set of gene annotations.
Available information includes: Announcements, Overview, Access and Availability, Collaborators, CCDS Identifiers and Tracking, Process Flow and Quality Testing, Publications.
Initial results from the Consensus CDS project are now available from the participants' genome browser Web sites. In addition, CCDS identifiers are indicated on the relevant NCBI RefSeq and Entrez Gene records. CCDS reports can be accessed by following provided links, or by directly querying the underlying database using the query interface provided at the top of the home page. The CCDS dataset is also available for anonymous FTP.
Identifies the conserved domains present in a protein sequence. CD-Search uses RPS-BLAST (Reverse Position-Specific BLAST) to compare a query sequence against position-specific score matrices that have been prepared from conserved domain alignments present in the Conserved Domain Database (CDD).
DailyMed provides high quality information about marketed drugs. This information includes FDA labels (package inserts). This Web site provides health information providers and the public with a standard, comprehensive, up-to-date, look-up and download resource of medication content and labeling as found in medication package inserts. The National Library of Medicine (NLM) provides this as a public service and does not accept advertisements.
dbSNP contains human single nucleotide variations, microsatellites, and small-scale insertions and deletions along with publication, population frequency, molecular consequence, and genomic and RefSeq mapping information for both common variations and clinical mutations. dbSNP tutorials can be found at https://github.com/ncbi/dbsnp/tree/master/tutorials
The 17,000 NHANES images are available in the following formats:
jpg - full spatial resolution and 8-bit grayscale
jpgahe – jpg with adaptive histogram equalization (AHE)
jpgaheus - jpg with adaptive histogram equalization (AHE) followed by unsharp masking
tif8 - full spatial resolution and 8-bit grayscale resolution in TIFF format
tif8roi - A small subset of the cervical spine images is available at full spatial resolution and 8-bit, cropped to regions of interest containing the spine area
fullres - The 17,000 NHANES II images at full spatial and full 12-bit grayscale resolution, in raw "nh2" format, uncompressed
marks - Vertebra coordinate values for a subset of about 600 of the images is available in ASCII text format
Information about the Second National Health and Nutrition Examination Survey (NHANES II)
The National Health and Nutrition Examination Surveys
The National Health and Nutrition Examination Surveys (NHANES), conducted by the National Center for Health Statistics, Centers for Disease Control (NCHS/CDC), were designed to assess the health and nutritional status of adults and children in the United States through interviews and direct physical examinations.
These images are the digitized versions of the 17,000 x-ray films collected during the Second National Health and Nutrition Examination Survey (NHANES II) conducted by the NCHS during the years 1976-1980. In NHANES II 20,322 individuals were both interviewed and examined. For examined persons aged 25 through 74, two x-rays were made, with the exceptions that no x-rays were taken of pregnant women and no lumbar x-rays were taken on women under 50 years of age. X-rays of the cervical and lumbar spines were taken to provide evidence of osteoarthitis and degenerative disc disease.
The films were subsequently digitized at a horizontal and vertical sampling rate of 146 dpi using Lumisys laser scanning equipment.
The NHANES radiographs were scanned by Dr. Bernie Huang at the University of California at Los Angeles and the University of California at San Francisco. Dr. Huang’s group used a Lumysis 100 with a 175 micron spot to scan the first 6000 radiographs. The remaining radiographs were scanned on the Lumysis 150 again with a 175 micron spot size.
NOTE: This dataset is no-longer updated with new content.