The Protein database is a collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB. Protein sequences are the fundamental determinants of biological structure and function.
TSA is an archive of computationally assembled transcript sequences from primary data such as ESTs and Next Generation Sequencing Technologies. The overlapping sequence reads from a complete transcriptome are assembled into transcripts by computational methods instead of by traditional cloning and sequencing of cloned cDNAs. The primary sequence data used in the assemblies must have been experimentally determined by the same submitter. TSA sequence records differ from GenBank records because there are no physical counterparts to the assemblies.
The Sequence Read Archive (SRA) stores sequencing data from the next generation of sequencing platforms including Roche 454 GS System®, Illumina Genome Analyzer®, Life Technologies AB SOLiD System®, Helicos Biosciences Heliscope®, Complete Genomics®, and Pacific Biosciences SMRT®.
This site is for browsing WGS (Whole Genome Shotgun) genomes, TSA (Transcriptome Shotgun Assemblies) and TLS (Targeted Locus Study) sets. WGS sequences are incomplete genomes that have been sequenced by a whole genome shotgun strategy. TSA sequences are transcript sequences that have been computationally assembled from primary RNA sequence data. TLS sequences are large-scale marker gene sequencing studies.